Synthesis of 9-CD3-9-cis-retinal cofactor of isorhodopsin
نویسندگان
چکیده
منابع مشابه
SYNTHESIS OF 1,4,8 - TRIHYDROXY- 9 (1 0 H) - ANTHRACENONE
The title compound has been synthesized starting from 2-methoxybenzdiethylarnide (1).
متن کاملSynthesis of 1-Hydroxy-2-(Prop-2'-Enyl) 9-Antrone
An efficient synthesis of the 1-hydroxy-2-(prop-2'-enyl)9-anthrone is described. Selective nitration of anthraquinone, reduction to the corresponding amine, diazotization and treatment by sulfuric acid solution afforded the 1-hydroxy-9,10-anthraquinone in good yield as the key intermediate. Reaction with allyl bromide/K2CO3 and subsequent selective reduction accompanie...
متن کاملREGIOSPECIFIC SYNTHESIS OF 1,6- DIMETHY L-9,lO-ANTHRACENEDIONE
Treatment of acetyl- 1,4-benzoquinone with isoprene gave the corresponding regioselective adduct (I). Rearrangement of the adduct (1) in pyridine and methanol gave 2-acetyl-5, 8-dihydro-6-methyl- 1,4-dihydroxynaphthalene (2). Silver oxide oxidation of the rearranged product (2) gave 2-acetyl-5,8-dihydro- 6-methyl- 1,4naphthalenedione (3). Regioselective addition of trans-piperylene to this...
متن کاملImprovement of visual performance with intravitreal administration of 9-cis-retinal in Rpe65-mutant dogs.
OBJECTIVE To determine the efficacy of intravitreal administration of 9-cis-retinal in restoring visual function in Rpe65-mutant dogs. METHODS Intravitreal injection of 9-cis-retinal was administered in 1 eye of 7 Rpe65-/- dogs at a range of ages. Electroretinogram analysis and testing of visual performance was used to evaluate outcomes after a single injection and in 2 dogs after a second in...
متن کاملThe identification of a 9-cis retinol dehydrogenase in the mouse embryo reveals a pathway for synthesis of 9-cis retinoic acid.
The ligand-controlled retinoic acid (RA) receptors and retinoid X receptors are important for several physiological processes, including normal embryonic development, but little is known about how their ligands, all-trans and 9-cis RA, are generated. Here we report the identification of a stereo-specific 9-cis retinol dehydrogenase, which is abundantly expressed in embryonic tissues known to be...
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ژورنال
عنوان ژورنال: Tetrahedron Letters
سال: 2018
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2018.11.034